BASIC/CLINICAL SCIENCE LAM CONFERENCE, MARCH 22-24, 2002
Conference Chairs Frank McCormack, MD
Elizabeth Henske, MD
Eugene Sullivan, MD
Session I Smooth Muscle Chair, Ray Panettieri, MD
Talmadge King, Jr., MD "What is known about the presentation, pathogenesis and treatment of LAM"
Deborah Hunter, PhD "What is known about the molecular and cellular biology of LAM"
Marvin Schwarz, MD "Smooth muscle infiltration in interstitial lung disease"
Presentations Blanca Camoretti-Mercado, PhD "Over-expression of Tuberin Regulates Promoter Activity of the Key Enzyme in the Mevalonate Pathway in Airway Smooth Muscle Cells"
Angelo Taveira-DaSilva, MD, PhD "Maximum Oxygen Uptake (VO2max) As A Test Of Severity Of Disease In Lymphangioleiomyomatosis (LAM). "
Session Keynote Kurt R. Stenmark, MD "Control of vascular smooth muscle cell proliferation indevelopment and disease"
Session II Hormones Chair, Blanca Camoretti-Mercado, PhD
Session Keynote Donald McDonnell, PhD "Estrogen receptor-cofactor interactions as targets for new drug discovery"
Session Keynote Richard Santen, MD "How does estrogen cause cells to grow?"
Presentations Geraldine Finlay, MD "Autocrine production of platelet-derived growth factor potentiates MAP kinase activation to mediate estrogen-induced proliferation of ELT-3 cells"
Guillermo Flores-Delgado, PhD "Nongenomic Estrogen Action In Lung Myofibroblasts Stimulates Erk1/2 Map Kinase And Igfr Phosphorylation"
Nancy Ayres Rice, PhD "Transcriptional regulation of skeletal muscle myosin expression in pulmonary myofibroblasts"
Brian Fouty, MD "TRAIL induces apoptosis in LAM- like cells"
Session III Cell Biology Chair, Jilly Evans, PhD
Session Keynote Richard Lamb, PhD "Functions of TSC tumour suppressor proteins and possible relationships to LAM pathology"
Session Keynote Joel Moss, MD, PhD "NHLBI intramural research program"
Janet Maurer, MD "Lung transplantation in LAM"
Presentations Jeanine D'Armiento, MD, PhD "A Transgenic Mouse Model of Pulmonary Lymphangiomyomatosis (LAM)"
Jonathan Moreno, MD, PhD
Vera Krymskaya, PhD "Determinants of Elastin Production by Smooth Muscle Cells"
Merv Merrilees, MD "Tuberin Regulates Activation Of S6K1 And Ribosomal Protein S6"
Session IV TSC and Genetics Chair, Deborah Hunter, PhD
Session Keynote Dicky Halley, PhD "LAM and TSC: a genetic relationship?"
Session Keynote Mark Brantly, MD "Issues in clinical trial design for rare diseases"
Presentations Aristotelis Astrinidis, PhD "Tuberin Regulates Rho Activation, Cell Adhesion, and Cell Migration"

Nisreen El-Hashemite, PhD "A TSC1 mouse model reveals sex dependent lethality from Liver Hemangioma: a future model for LAM"
Magdalena Karbowniczek, MD, PhD "Renal Angiomyolipomas from Women with Sporadic Lymphangiomyomatosis Contain Both Neoplastic and Reactive Vascular Structures"
Dan Noonan, PhD "Molecular Analyses of TSC2-Mediated Intracellular Signaling Pathways"
Vijaya Ramesh, PhD "Pam (Protein Associated With Myc), A Novel Interactor For TSC2 Protein Tuberin"
Posters Jane Yu, PhD Estrogen Stimulates the Growth of Cultured Cells from Lymphangiomyomatosis-Associated Angiomyolipoma

James Michael Shipley, PhD Disruption of TSC2 Function in Adult Mice
Marsha Cohen, MD, FRCPC Preliminary results of a survey to assess Psychosocial Outcomes Pre and Post Lung Transplant for women with LAM
John Bissler, MD Replication Consequences of a Polypurine·Polypyrimidine Tract Near the TSC2 Gene
Eric Olson, MD Chylothorax in Lymphangioleiomyomatosis
Nicole Griffith, MS Construction of TSC1 and TSC2 Adenovirus Clones